Ceramide 1-Phosphate: First, Second, or Dual Messenger?
نویسندگان
چکیده
منابع مشابه
Ceramide: second messenger or modulator of membrane structure and dynamics?
The physiological role of ceramide formation in response to cell stimulation remains controversial. Here, we emphasize that ceramide is not a priori an apoptotic signalling molecule. Recent work points out that the conversion of sphingomyelin into ceramide can play a membrane structural (physical) role, with consequences for membrane microdomain function, membrane vesiculation, fusion/fission a...
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It has been over a decade since the sphingolipid ceramide-1-phosphate (C1P) was described. Until recently, only sparse reports on possible biological functions for this lipid have been published. A large number of reports have now surfaced demonstrating distinct biological mechanisms regulated by C1P produced from ceramide kinase (CERK). In the following methods chapter, the methodologies for e...
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Cannabinoids, the active components of Cannabis sativa (marijuana), and their endogenous counterparts exert their effects by binding to specific G(i/o)-protein-coupled receptors that modulate adenylyl cyclase, ion channels and extracellular signal-regulated kinases. Recent research has shown that the CB(1) cannabinoid receptor is coupled to the generation of the lipid second messenger ceramide ...
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It is now well established that glycerophospholipids and their metabolic products (such as diacylglycerol (DAG), inositol trisphosphate, eicosanoids, and platelet-activating factor) function in signal transduction and cell regulation (14). On the other hand, a role for membrane sphingolipids in signal transduction has not been well appreciated although sphingolipids exhibit even greater structu...
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In the last two decades there has been considerable progress in our understanding of the role of sphingolipids in controlling signal transduction processes, particularly in the mechanisms leading to regulation of cell growth and death. Ceramide is a well-characterized sphingolipid metabolite and second messenger that can be produced by cancer cells in response to a variety of stimuli, including...
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ژورنال
عنوان ژورنال: Journal of Membrane Science & Technology
سال: 2012
ISSN: 2155-9589
DOI: 10.4172/2155-9589.1000e107